Thermo Fisher Scientific DREAM Polyclonal Antibody
인간 DREAM 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, 단백질 발현 연구용으로 적합. Protein A로 정제된 액상 제품으로, PBS buffer에 보존제 없이 제공. -20°C에서 보관 권장.
- 카탈로그번호
- 70149-100UG
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to amino acids 26–35 of human DREAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system. In the heart, Kv4 channels contribute to the repolarization phase of the action potential, while in the brain, they prevent reverse propagation of action potentials.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels and modulate their function. There are three known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (with isoforms a, b, c)
- KChIP3 (DREAM/calsenilin): Expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also acts as a DNA-binding transcriptional regulator by binding to the regulatory DRE and repressing transcription of early-response genes such as c-fos. It is also associated with presenilins and implicated in β-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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