Thermo Fisher Scientific EXD2 Polyclonal Antibody

Applications

Tested Application

• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution

Product Specifications

Product Specific Information

Immunogen sequence:
SKTSPVTQQP QQKVLGSREL PPPEDDQLHS SAPRSSWKER ILKAKVVTVS QEAEWDQIEP LLRSELEDFP VLGIDCEWER HGTYLQWLF

Antigen sequence identity (orthologs):

• Mouse: 60%
• Rat: 58%

Target Information

EXD2 is an exonuclease exhibiting both 3′–5′ exoribonuclease and exodeoxyribonuclease activities depending on the divalent metal cation used as cofactor.

• With Mg²⁺: shows only 3′–5′ exoribonuclease activity
• With Mn²⁺: shows both exoribonuclease and exodeoxyribonuclease activities

Functions include:

• Acts as an exoribonuclease in mitochondria, regulating ATP production and mitochondrial translation
• Involved in DNA damage response and double-strand break repair
• Plays a key role in homologous recombination and chromosomal break repair
• Recruited to chromatin in a damage-dependent manner and interacts with the MRN complex to accelerate resection
• Stabilizes and restarts stalled replication forks under replicative stress

[Source: UniProt]

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.