Thermo Fisher Scientific EXD2 Polyclonal Antibody
Rabbit polyclonal antibody against human EXD2, validated for IHC (paraffin). Recognizes recombinant EXD2 protein. Suitable for studies on DNA repair, mitochondrial function, and replication stress response. For research use only.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EXD2. Recombinant protein control fragment: Product #RP-89043 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641155 |
Product Specific Information
Immunogen sequence:
SKTSPVTQQP QQKVLGSREL PPPEDDQLHS SAPRSSWKER ILKAKVVTVS QEAEWDQIEP LLRSELEDFP VLGIDCEWER HGTYLQWLF
Antigen sequence identity (orthologs):
- Mouse: 60%
- Rat: 58%
Target Information
EXD2 is an exonuclease exhibiting both 3′–5′ exoribonuclease and exodeoxyribonuclease activities depending on the divalent metal cation used as cofactor.
- With Mg²⁺: shows only 3′–5′ exoribonuclease activity
- With Mn²⁺: shows both exoribonuclease and exodeoxyribonuclease activities
Functions include:
- Acts as an exoribonuclease in mitochondria, regulating ATP production and mitochondrial translation
- Involved in DNA damage response and double-strand break repair
- Plays a key role in homologous recombination and chromosomal break repair
- Recruited to chromatin in a damage-dependent manner and interacts with the MRN complex to accelerate resection
- Stabilizes and restarts stalled replication forks under replicative stress
[Source: UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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