Thermo Fisher Scientific Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AH36), PerCP
Phospho-Tau (Ser202, Thr205) 단백질을 인식하는 AH36 클론의 PerCP 결합 단클론 항체. Western blot, IHC, ICC/IF, ELISA, Dot blot에 사용 가능. 인간 및 마우스 반응성. 액상 형태, 1 mg/mL 농도, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:500 |
| ELISA | Assay-dependent |
| Dot blot (DB) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AH36 |
| Immunogen | Synthetic peptide of Human Phospho Tau (Ser202/Thr205) |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932389 |
Additional Formats
Product Specific Information
A 1:500 dilution of MA5-45935 was sufficient for detection of Tau in 10 µg Baculovirus by dot blot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody. Detects approximately 79 kDa.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker protein. Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize it. Hyper-phosphorylated Tau forms paired helical filaments (PHF), a major component of neurofibrillary lesions in Alzheimer’s disease. This modification impairs microtubule binding, leading to destabilization and neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other CNS disorders including Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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