Thermo Fisher Scientific NOXA Polyclonal Antibody
Thermo Fisher Scientific의 NOXA Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ICC/IF에 사용 가능합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 세포사멸 연구 및 p53 관련 경로 분석에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | – |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154096 |
Product Specific Information
- Suggested positive control: Human stomach tissue lysate
- PA5-19977 can be used with blocking peptide PEP-0305.
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, encodes a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels.
When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, leading to caspase-9 activation. Like PUMA, Noxa localizes to mitochondria and induces apoptosis in response to p53.
Increased levels of p53 and its target gene Noxa have been observed in impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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