Thermo Fisher Scientific SUMO1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The antigen is homologous in human, rat, and marmoset.
• Specificity: SUMO1.

Target Information

SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Its covalent attachment requires activation by the E1 complex (SAE1-SAE2), transfer to the E2 enzyme (UBE2I), and may be promoted by E3 ligases such as PIAS1–4, RANBP2, or CBX4.
This post-translational modification plays a critical role in cellular processes including nuclear transport, DNA replication and repair, mitosis, and signal transduction.
SUMO1 is involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains can undergo polyubiquitination, signaling proteasomal degradation of modified proteins.
Additionally, SUMO1 may regulate genes involved in palate development, and mutations in its gene are associated with non-syndromic orofacial cleft 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.