Thermo Fisher Scientific SCNN1G Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:1,000–1:2,000
• Publications: 1 publication available (Miscellaneous PubMed)

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCNN1G.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels share a common structure with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a conserved cysteine-rich region.

There are three homologous isoforms of ENaC: alpha, beta, and gamma.
ENaC in the kidney, lung, and colon regulates trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, affecting blood pressure regulation.

ENaC function is partly regulated by association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.