Thermo Fisher Scientific SCNN1G Polyclonal Antibody
SCNN1G 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. IHC에 적합하며, mouse 시료에 반응. 합성 펩타이드 항원 사용, 동결건조 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- OSS00104W-100UL
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:1,000–1:2,000
- Publications: 1 publication available (Miscellaneous PubMed)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular domain of mouse amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC) conjugated to immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCNN1G.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels share a common structure with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC: alpha, beta, and gamma.
ENaC in the kidney, lung, and colon regulates trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, affecting blood pressure regulation.
ENaC function is partly regulated by association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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