Thermo Fisher Scientific STAM 1, 2 Polyclonal Antibody
STAM1 및 STAM2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. 인간, 마우스, 랫드 등 다양한 종에 반응하며, PBS 기반으로 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long term, store at −20 °C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water and centrifuge to remove any insoluble material.
- The peptide is homologous in many species including rat, mouse, zebrafish, and xenopus.
- Specificity: STAM1 and STAM2.
Target Information
STAM1:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSF stimulation, it contributes to signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking and T-cell development.
Subunit: Heterodimer composed of STAM1 and HGS/HRS. Interacts with STAMBP/AMSH.
Tissue Specificity: Ubiquitously expressed.
STAM2:
Participates in intracellular signal transduction mediated by cytokines and growth factors, likely through association with ubiquitinated cargo proteins on early endosomes for lysosomal trafficking. Upon IL-2 and GM-CSF stimulation, contributes to DNA synthesis and c-myc induction, and may play a role in T-cell development.
Subunit: Heterodimer or heterotrimer composed of STAM2 and HGS/HRS; may include EPS15. Interacts with STAMBP/AMSH, JAK2, JAK3, ubiquitinated proteins, USP8/UBPY, CBX5 (via PxVxL motif), and VPS37C.
Tissue Specificity: Ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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