Thermo Fisher Scientific SCNN1A Polyclonal Antibody

Thermo Fisher Scientific SCNN1A Polyclonal Antibody

Applications

• Immunohistochemistry (IHC)
  Tested Dilution: 1:300–1:2,000

Publications

• Miscellaneous PubMed (Misc): None
• View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCNN1A.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of ENaC: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance. It mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thereby regulating blood pressure. ENaC is thought to be regulated partly through association with the CFTR chloride ion channel. Gain-of-function mutations in beta or gamma ENaC can cause severe arterial hypertension (Liddel’s syndrome), while loss-of-function mutations in alpha or beta ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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