Thermo Fisher Scientific SCNN1A Polyclonal Antibody
SCNN1A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Rat 시료 반응성 검증 완료. IHC에 1:300~1:2,000 희석 비율로 사용 가능. Lyophilized 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용 전용 제품.
- 카탈로그번호
- OSS00103W-100UL
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 1t cytoplasmic domain of rat amiloride sensitive sodium channel subunit alpha (SCNN1A, SCNEA, Alpha-ENaC) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCNN1A.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels share structural similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC: alpha, beta, and gamma.
ENaC in kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance and mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
ENaC is partially regulated through association with the CFTR chloride ion channel.
Gain-of-function mutations in beta or gamma ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha or beta ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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