Thermo Fisher Scientific RIG-I Polyclonal Antibody
Thermo Fisher Scientific의 RIG-I Polyclonal Antibody는 인간 RIG-I 단백질을 인식하는 토끼 유래 IgG 항체로, 면역세포 염색(ICC/IF)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 저장 버퍼를 사용합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific RIG-I Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human RIG-I. Recombinant protein control fragment (Product #RP-104832) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856663 |
Product Specific Information
Immunogen sequence:
NREFGTQKYE QWIVTVQKAC MVFQMPDKDE ESRICKALFL YTSHLRKYND ALIISEHARM KDALDYLKDF FSNVRAAGFD EIEQDLTQRF EEKLQELESV SRDPSNENPK LEDLCFILQE EYHLNPETIT ILFVK
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in viral dsRNA recognition. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases with overlapping and distinct roles.
RIG-I is activated by dsRNAs lacking a 5'-triphosphate end and short dsRNAs, whereas MDA5 responds to long dsRNAs. Once activated, both proteins signal through IPS-1, activating transcription factors NF-kappaB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A/B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I targets TRAF6, IRAK1, and IRAK2, providing feedback inhibition of antiviral response.
Recent evidence also implicates RIG-I in cytosolic DNA detection through RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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