Thermo Fisher Scientific RIG-I Polyclonal Antibody

Thermo Fisher Scientific RIG-I Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
NREFGTQKYE QWIVTVQKAC MVFQMPDKDE ESRICKALFL YTSHLRKYND ALIISEHARM KDALDYLKDF FSNVRAAGFD EIEQDLTQRF EEKLQELESV SRDPSNENPK LEDLCFILQE EYHLNPETIT ILFVK

Target Information

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in viral dsRNA recognition. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases with overlapping and distinct roles.
RIG-I is activated by dsRNAs lacking a 5'-triphosphate end and short dsRNAs, whereas MDA5 responds to long dsRNAs. Once activated, both proteins signal through IPS-1, activating transcription factors NF-kappaB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A/B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I targets TRAF6, IRAK1, and IRAK2, providing feedback inhibition of antiviral response.
Recent evidence also implicates RIG-I in cytosolic DNA detection through RNA polymerase III activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)