Thermo Fisher Scientific TSC2 Recombinant Rabbit Monoclonal Antibody (SC05-59)
TSC2 단백질을 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합합니다. HEK293 세포에서 발현되며, 일관된 로트 간 품질을 보장합니다.
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Thermo Fisher Scientific TSC2 Recombinant Rabbit Monoclonal Antibody (SC05-59)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC05-59 |
| Immunogen | Synthetic peptide within Human Tuberin aa 1760–1807 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809477 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex subunit 2) acts as a tumor suppressor and may function in vesicular transport and regulation of cell growth arrest. It associates with hamartin (TSC1) forming a cytosolic complex that regulates transcription mediated by steroid receptors. Phosphorylation of tuberin on Ser939 and Thr1462 modulates its interaction with hamartin via the PI3K/Akt pathway. TSC2 also stimulates the GTPase activity of RAP1A and RAB5, implicating its role in cell growth regulation. Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and angiomyolipoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-32190_TSC2_P49815-1_Rabbit.svg, MA5-32190_TSC2_P49815-1_Rabbit_PDP.jpeg)
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