Thermo Fisher Scientific AKR1C2 Monoclonal Antibody (3C11)
인간 AKR1C2 단백질을 인식하는 mouse monoclonal antibody로 Western blot과 ELISA에 적합. 비결합형 액상 형태로 제공되며, -20°C에서 보관. xenobiotic 및 스테로이드 대사 관련 연구용으로 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C11 |
| Immunogen | AKR1C2 (AAH63574, 224–323 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEPWVDPNSP VLLEDPVLCA LAKKHKRTPA LIALRYQLQR GVVVLAKSYN EQRIRQNVQV FEFQLTSEEM KAIDGLNRNV RYLTLDIFAG PPNYPVSDEY
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3α-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are 3α-HSDs.
Human cytosolic dihydrodiol dehydrogenases are involved in metabolism of xenobiotics (e.g., polycyclic aromatic hydrocarbons, pesticides, steroid hormones) and reduction of ketone-containing drugs using NADH or NADPH as cofactors.
20α-HSD catalyzes the conversion of progesterone to the inactive 20α-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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