Thermo Fisher Scientific DDX1 Monoclonal Antibody (4F6)
DDX1 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 DDX1에 반응하며, PBS(pH 7.4) 저장용액에 보존제 없이 제공됩니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific DDX1 Monoclonal Antibody (4F6)
Applications and Tested Dilution
- Western Blot (WB): 1–5 µg/mL
- ELISA: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F6 |
| Immunogen | DDX1 (NP_004930, 642–740 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RLKEDGGCTI WYNEMQLLSE IEEHLNCTIS QVEPDIKVPV DEFDGKVTYG QKRAAGGGSY KGHVDILAPT VQELAALEKE AQTSFLHLGY LPNQLFRTF
Target Information
DDX1 (ATP-dependent RNA helicase DDX1) acts as an ATP-dependent RNA helicase capable of unwinding both RNA-RNA and RNA-DNA duplexes. It possesses 5′ single-stranded RNA overhang nuclease activity and ATPase activity on various RNA substrates, but not DNA.
DDX1, together with RELA, functions as a coactivator enhancing NF-kappa-B-mediated transcriptional activation and positively regulates cyclin CCND2 expression by binding to its promoter region.
It is a component of a multi-helicase–TICAM1 complex that senses viral double-stranded RNA in the cytoplasm and activates antiviral responses, including induction of proinflammatory cytokines via TICAM1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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