Thermo Fisher Scientific AKR1C2 Monoclonal Antibody (3C11)
AKR1C2 단백질을 인식하는 Mouse monoclonal antibody (clone 3C11). Western blot 및 ELISA에 적합하며, 인간 시료에 반응합니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C11 |
| Immunogen | AKR1C2 (AAH63574, 224 a.a. ~ 323 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
EEPWVDPNSP VLLEDPVLCA LAKKHKRTPA LIALRYQLQR GVVVLAKSYN EQRIRQNVQV FEFQLTSEEM KAIDGLNRNV RYLTLDIFAG PPNYPVSDEY
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are 3 alpha-HSDs.
The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics such as polycyclic aromatic hydrocarbons, pesticides, and steroid hormones. They are responsible for the reduction of ketone-containing drugs using NADH or NADPH as cofactors. The 20 alpha-HSD catalyzes the conversion of progesterone to its inactive form, 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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