Thermo Fisher Scientific AKR1C2 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNH RLLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

Target Information

DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are the 3 alpha-HSDs.
The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics such as polycyclic aromatic hydrocarbons, pesticides, and steroid hormones, and are responsible for the reduction of ketone-containing drugs using NADH or NADPH as a cofactor.
The 20 alpha-HSD catalyzes the reaction of progesterone to the inactive form 20 alpha-hydroxyprogesterone.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.