Thermo Fisher Scientific MEP1B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_0059162) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEP1B,uniProtId:Q16820-1,ncbiNodeId:9606,antigenRange:480-652,antigenLength:701,antigenImageFileName:PA5-87627_MEP1B_Q16820-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87627_MEP1B_Q16820-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804300

Product Specific Information

Immunogen sequence: ISGANDDQLQ WPCPWQQATM TLLDQNPDIR QRMSNQRSIT TDPFMTTDNG NYFWDRPSKV GTVALFSNGT QFRRGGGYGT SAFITHERLK SRDFIKGDDV YILLTVEDIS HLNSTQIQLT PAPSVQDLCS KTTCKNDGVC TVRDGKAECR CQSGEDWWYM GERCEKRGST RDT; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.