Thermo Fisher Scientific Aminoacylase 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where its expression is often reduced or undetectable. The human aminoacylase-1 sequence is highly homologous to the porcine enzyme and represents the first member of a zinc-binding enzyme family. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder with central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing and read-through transcription with ABHD14A are known, and a pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.