Thermo Fisher Scientific Sodium Channel Pan Polyclonal Antibody
Rabbit polyclonal antibody recognizing pan sodium channels in human, mouse, and rat. Suitable for WB, IHC, and ICC applications. Affinity-purified, supplied as liquid at 1 mg/mL in PBS with 50% glycerol. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SCN1A (Accession P35498), corresponding to amino acid residues F1486–D1536 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853766 |
Product Specific Information
Antibody detects endogenous levels of total pan Sodium Channel.
Target Information
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na⁺ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1–NaV1.9.
NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX):
- TTX-sensitive: NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6, NaV1.7
- TTX-resistant: NaV1.5, NaV1.8, NaV1.9
Mammalian sodium channels are heterotrimers, composed of a central pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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