Thermo Fisher Scientific Phospho-p27 Kip1 (Ser10) Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal 항체로, p27 Kip1 Ser10 인산화 부위를 인식합니다. Western Blot 및 ELISA에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 안정적인 저장 및 높은 특이성을 제공합니다.
- 카탈로그번호
- PA540207
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-p27 Kip1 (Ser10) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human p27 around the phosphorylation site of S10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608736 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
p27 Kip1 functions as a negative regulator of G1 progression and may mediate TGF-β induced G1 arrest. It is a key regulator of cell cycle progression and inhibits cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 interacts with cyclin D-CDK4 complexes, influencing their assembly and activation. Its activity depends on phosphorylation state and stoichiometry. The protein (~27 kDa) undergoes CDK-dependent phosphorylation and ubiquitination by SCF complexes, enabling transition from quiescence to proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.