Thermo Fisher Scientific FGFR2 Recombinant Rabbit Monoclonal Antibody (JM10-60)
FGFR2 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 면역침강(IP)에 적합. 높은 특이성과 재현성을 제공하며, 로트 간 일관성이 우수함. 단백질 A로 정제된 액상 제품으로 4°C 또는 -20°C에서 안정적으로 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM10-60 |
| Immunogen | Synthetic peptide within Human FGFR2 (aa 30–70) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809906 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select optimal clones for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
FGFR2 (Fibroblast Growth Factor Receptor 2) is a receptor tyrosine kinase that regulates diverse cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair.
It is implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Mutations in FGFR2 are associated with several syndromes, including:
- Crouzon syndrome
- Pfeiffer syndrome
- Craniosynostosis
- Apert syndrome
- Jackson-Weiss syndrome
- Beare-Stevenson cutis gyrata syndrome
- Saethre-Chotzen syndrome
Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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