Thermo Fisher Scientific IL-10 Monoclonal Antibody (945A4C437B1)
IL-10 단백질을 표적으로 하는 마우스 단클론 항체로, 다양한 종(햄스터, 돼지, 랫드)에서 사용 가능. ELISA, 유세포분석, 중화시험 등 다중 응용에 적합. 액상 형태, 1 mg/mL 농도, -20°C 보관. 면역조절 및 염증 연구에 활용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA | Assay-dependent | View 2 publications |
| Neutralization (Neu) | - | View 1 publication |
| Luminex (LUM) | - | View 1 publication |
| Affinity Purification (AP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Hamster, Pig, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 945A4C437B1 |
| Immunogen | Recombinant swine IL-10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536419 |
Target Information
IL-10 encodes a cytokine primarily produced by monocytes, with additional production by lymphocytes. It plays a key role in immunoregulation and inflammation by:
- Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
- Enhancing B cell survival, proliferation, and antibody production
- Blocking NF-kappa B activity
- Regulating the JAK-STAT signaling pathway
Knockout studies in mice indicate IL-10 is essential for intestinal immune regulation. Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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배송/결제/교환/반품 안내
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