Thermo Fisher Scientific MEF2C Polyclonal Antibody
Rabbit polyclonal antibody targeting human MEF2C. Validated for WB, IHC(P), and ICC/IF. Recognizes MEF2C involved in muscle and neuronal development. Supplied as liquid, 0.4 mg/mL, stored at 4°C or -20°C. For research use only.
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- PA513287
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 365–394 of human MEF2C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980556 |
Product Specific Information
This antibody is predicted to react with porcine based on sequence homology.
Target Information
MEF2C is a transcription activator binding specifically to the MEF2 element in regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis, and is involved in vascular development. MEF2C plays an essential role in hippocampal-dependent learning and memory by regulating excitatory synapses and synaptic transmission. It is crucial for neuronal development, distribution, and electrical activity in the neocortex, and necessary for proper development of megakaryocytes, platelets, and B lymphopoiesis. MEF2C is required for B-cell survival and proliferation, efficient IgG1 antibody responses, and normal induction of germinal center B cells. It may also contribute to neurogenesis and cortical architecture development. Isoforms 3 and 4, lacking the repressor domain, are more active than isoforms 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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