Thermo Fisher Scientific GRB2 Polyclonal Antibody
Rabbit polyclonal antibody against human GRB2 protein. Validated for WB and IHC (Paraffin). Predicted cross-reactivity with mouse, rat, and Xenopus. Suitable for research use only; not for diagnostic applications.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 89–118 of human GRB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Size-exclusion, dialysis, ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2113009 |
Product Specific Information
This antibody is predicted to react with mouse, rat, and Xenopus based on sequence homology.
Target Information
GRB2 protein contains one SH2 domain flanked by two SH3 domains. In response to EGF, GRB2 binds through its SH3 domains to the guanine nucleotide exchange factor Sos. The GRB2–Sos complex then associates with the EGF receptor, playing a critical role in activation of the p21^ras^ signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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