
Thermo Fisher Scientific LRRK2 Monoclonal Antibody (N231B/34), APC
LRRK2 단백질을 인식하는 마우스 단클론 항체로, APC 형광표지되어 있습니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 인간 및 랫트 시료에 반응합니다. 단백질 G 정제, 보존제 무첨가, 4°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N231B/34 |
| Immunogen | Fusion protein amino acids 841–960 of human LRRK2 |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932095 |
Additional Formats
- FITC: MA5-45642
- PerCP: MA5-45643
- Request custom conjugation
Product Specific Information
- 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
- 10 µg/mL of MA5-45641 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects >200 kDa.
- This antibody was formerly sold as clone S231B-34.
Target Information
LRRK2 (Leucine-rich repeat kinase 2) is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson’s disease.
LRRK2 encodes a protein with ankyrin repeat, LRR, kinase, DFG-like motif, RAS, GTPase, MLK-like, and WD40 domains. The protein is mainly cytoplasmic but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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