Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser118) Monoclonal Antibody (G.194.4)
인간 ERα의 Ser118 인산화를 인식하는 단클론 항체로, Western blot과 IHC(파라핀 절편)에 적합합니다. 교차 반응성이 없으며, 액상 형태로 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G.194.4 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer118 of human ERα |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10981351 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with phosphorylated estrogen receptor-beta.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha and beta, encoded by ESR1 and ESR2 genes. Alternative RNA splicing produces at least four estrogen receptor-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). ERs are widely expressed across tissues, essential for sexual development and reproductive function, and involved in bone metabolism. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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