Thermo Fisher Scientific BCR Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal 항체로 BCR 단백질 검출에 적합. IHC(P)에서 1:50~1:200 희석으로 사용 가능. 고순도(>95%) 항체로 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 321–370 of Human Bcr |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803061 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene.
The translocation produces a fusion protein encoded by sequences from both BCR and ABL, the gene at the chromosome 9 breakpoint.
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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