Thermo Fisher Scientific B-Raf Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal B-Raf 항체로, WB 및 IHC(P) 실험에 적합합니다. 고순도(>95%)로 정제되었으며, 액상 형태로 1 mg/mL 농도입니다. MAPK/ERK 신호전달 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 560–610 of Human Raf-B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803062 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
BRAF is involved in transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer and plays a role in postsynaptic responses of hippocampal neurons. This protein regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion. Mutations in B-Raf are associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene located on chromosome X has been identified for B-Raf.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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