Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI4H5), TrueMAB
인간 TNFRSF18(GITR) 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot 및 Flow cytometry에 적합. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도 권장. 연구용 전용 항체로 T세포 활성화 및 면역 조절 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 26–162 of human TNFRSF18 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene located on chromosome 1p36.33.
This receptor is part of the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in immunological self-tolerance maintained by CD25⁺CD4⁺ regulatory T cells.
Mouse knockout studies suggest its involvement in CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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