Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI2F8), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family.
It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit SHP-1 and SHP-2 phosphatases for signaling and are involved in receptor internalization.
CD33 is expressed on cells of the myelomonocytic lineage, binding sialic acid residues on N- and O-glycans, and serves as a therapeutic target for acute myeloid leukemia (AML).
It is present on granulocyte and macrophage precursors in bone marrow and peripheral monocytes, but not on pluripotent stem cells.
CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemia cells.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.