Thermo Fisher Scientific Syk Polyclonal Antibody
SYK 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로 Western blot, IHC, IP에 사용 가능. 합성 펩타이드 면역원 기반으로 제작되었으며, 비결합형 액상 형태. 알레르기·자가면역·암 연구용으로 적합.
- 카탈로그번호
- PA532605
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from internal region of human SYK protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550070 |
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining using a 10 mM citrate buffer (pH 6.0) for 10 minutes, followed by cooling at room temperature for 20 minutes.
After antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature.
Suggested positive control: bone marrow or lymphoma.
Target Information
Spleen tyrosine kinase (SYK) is a cytoplasmic tyrosine kinase, along with ZAP70, considered a potential drug target for allergic and autoimmune diseases. SYK may also play a role in cancer.
Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, SYK translocates to the plasma membrane and phosphorylates downstream adaptor proteins, initiating signaling pathways such as calcium mobilization, cytoskeleton remodeling, and gene transcription.
SYK interacts with receptor ITAM motifs via its SH2 domains, which are phosphorylated by Src-family kinases that also activate SYK through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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