Thermo Fisher Scientific IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience

Thermo Fisher Scientific IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 0.125 µg/test
Publications: View 3 publications

Product Specifications

Additional Formats

• Functional Grade
• Request custom conjugation

Product Specific Information

The MAR1-5A3 monoclonal antibody reacts with mouse IFN alpha/beta receptor subunit 1 (IFNAR-1).
The type I IFN receptor subunit 1 is co-expressed with IFNAR-2 on nearly all cells and forms a heterodimeric receptor complex that binds to all type I IFNs (IFN alpha and IFN beta).
Type I IFNs are structurally and functionally related proteins with antiviral, antiparasitic, and antiproliferative activities.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered

Target Information

Interferons are therapeutic agents with anti-tumor and antiviral effects, and modulate immune responses (Biron, 2001; Kirkwood, 2002).
These cytokines act by binding to the Type I Interferon Receptor (IFNAR1).
Downregulation of IFNAR1 influences cytokine signaling magnitude and duration, possibly via phosphorylation of Serine 535 and 539 (Kumar et al., 2003).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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