Thermo Fisher Scientific IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience
마우스 IFNAR1을 인식하는 MAR1-5A3 단클론 항체로, PE 형광체가 결합된 제품입니다. Flow cytometry 분석에 최적화되어 있으며 0.125 µg/test로 사용 가능합니다. 565/576 nm의 Excitation/Emission 특성을 가지며, 4°C 암소 보관이 권장됩니다.
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Thermo Fisher Scientific IFNAR1 Monoclonal Antibody (MAR1-5A3), PE, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MAR1-5A3 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572646 |
Additional Formats
Product Specific Information
The MAR1-5A3 monoclonal antibody reacts with mouse IFN alpha/beta receptor subunit 1 (IFNAR-1).
The type I IFN receptor subunit 1 is co-expressed with IFNAR-2 on nearly all cells and forms a heterodimeric receptor complex that binds to all type I IFNs (IFN alpha and IFN beta).
Type I IFNs are structurally and functionally related proteins with antiviral, antiparasitic, and antiproliferative activities.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Interferons are therapeutic agents with anti-tumor and antiviral effects, and modulate immune responses (Biron, 2001; Kirkwood, 2002).
These cytokines act by binding to the Type I Interferon Receptor (IFNAR1).
Downregulation of IFNAR1 influences cytokine signaling magnitude and duration, possibly via phosphorylation of Serine 535 and 539 (Kumar et al., 2003).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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