Thermo Fisher Scientific HDAC8 Monoclonal Antibody (OTI5F7), TrueMAB
HDAC8 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트 반응성을 가지며, 재조합 인간 HDAC8(aa 1-243)을 면역원으로 제작되었습니다. 동결건조 형태이며 PBS와 trehalose buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–243 of human HDAC8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
In the intact cell, DNA associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a key component of transcriptional regulation, largely mediated by histone acetylation.
Acetylation of lysine residues in histone tails increases accessibility to transcription factors, while deacetylation is linked to transcriptional silencing.
HDAC8, a mammalian histone deacetylase isolated from human kidney, shares homology with other HDACs but exhibits distinct tissue distribution. It is localized to the nucleus and plays roles in tissue development and cancer etiology.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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