Thermo Fisher Scientific Reelin Recombinant Rabbit Monoclonal Antibody (JA63-13)
Reelin 단백질을 표적하는 재조합 토끼 모노클로날 항체로, Western blot 및 IHC(P)에서 높은 특이성과 재현성을 제공합니다. HEK293 발현 시스템으로 생산되어 로트 간 일관성이 우수하며, 동물 유래 성분이 없는 포뮬레이션입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA63-13 |
| Immunogen | Synthetic peptide within Human Reelin aa 3248–3297 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810000 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Reelin is an extracellular matrix serine protease involved in neuronal layering in the cerebral cortex and cerebellum. It regulates microtubule function and neuronal migration, influencing the positioning of sympathetic preganglionic neurons in the spinal cord. Reelin acts as a barrier to neuronal migration and modulates cell adhesion through enzymatic activity.
Binding to VLDLR and LRP8/APOER2 receptors induces tyrosine phosphorylation of DAB1 and affects TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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