Thermo Fisher Scientific Integrin beta 1 (CD29) Recombinant Rabbit Monoclonal Antibody (RM285)
Thermo Fisher Scientific의 Integrin beta 1 (CD29) 재조합 토끼 단클론 항체(RM285)는 높은 특이성과 감도를 제공하며, Western blot, IHC, ICC/IF에 적합합니다. HEK293 세포 발현 시스템에서 생산된 동물 유래 성분 없는 항체로 로트 간 일관성과 안정성이 우수합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM285 |
| Immunogen | A peptide corresponding to residues in human CD29 (Integrin beta-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.04 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744954 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed in various cells including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6), determining the binding properties of beta1 (VLA) integrins.
ITGB1 acts as a cell adhesion molecule on platelets and as a common beta subunit of the very late activation antigen (VLA). It participates in protein complexes binding to extracellular matrix proteins.
Decreased expression correlates with multidrug resistance in tumor cells. ITGB1 is upregulated in leukocytes during migration and plays a critical role in immune cell trafficking.
Additionally, ITGB1 regulates tissue damage and inflammatory responses such as those in inflammatory bowel disease. Fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle via ITGB1-dependent mechanisms.
There are two major forms of integrin beta1: beta1A and beta1D, differing by 13 amino acids. Beta1A is present in all tissues except cardiac and skeletal muscle, which express beta1D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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