Thermo Fisher Scientific Integrin beta 1 (CD29) Recombinant Rabbit Monoclonal Antibody (RM285)

Applications

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed in various cells including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6), determining the binding properties of beta1 (VLA) integrins.

ITGB1 acts as a cell adhesion molecule on platelets and as a common beta subunit of the very late activation antigen (VLA). It participates in protein complexes binding to extracellular matrix proteins.
Decreased expression correlates with multidrug resistance in tumor cells. ITGB1 is upregulated in leukocytes during migration and plays a critical role in immune cell trafficking.

Additionally, ITGB1 regulates tissue damage and inflammatory responses such as those in inflammatory bowel disease. Fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle via ITGB1-dependent mechanisms.
There are two major forms of integrin beta1: beta1A and beta1D, differing by 13 amino acids. Beta1A is present in all tissues except cardiac and skeletal muscle, which express beta1D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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