Thermo Fisher Scientific TNFRSF9 Monoclonal Antibody (OTI5H5), TrueMAB
인간 TNFRSF9(CD137, 4-1BB)을 인식하는 마우스 단클론 항체. Western blot에 최적화되어 있으며, 비접합형 동결건조 형태로 제공. 재구성 후 약 1 mg/mL 농도 유지 가능. 활성화된 T세포 관련 면역 연구에 적합.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 24–186 of human TNFRSF9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
CD137 (TNFRSF9, 4-1BB) is an inducible costimulatory molecule primarily expressed on activated T cells.
Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and expansion of activated and memory T cells while regulating myelopoiesis and dendritic cell development.
Triggered CD137 induces cytokine release profiles that influence peripheral monocyte survival.
Soluble CD137 may serve as a negative regulator in certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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