Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1E12), TrueMAB
TYMS 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. 인간 시료 반응성, 무보존제 PBS 버퍼에 동결건조 형태로 제공. DNA 합성 관련 효소 Thymidylate Synthase 연구용으로 사용.
- 카탈로그번호
- CF801764
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1E12), TrueMAB
Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1E12), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E12 |
| Immunogen | Full length human recombinant protein of human TYMS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a key target of fluoropyrimidine-based anticancer drugs such as 5-fluorouracil (5-FU) and fluorodeoxyuridine. These drugs form a ternary covalent complex with TS and folate cofactor 5,10-methylenetetrahydrofolate, leading to enzyme inactivation.
TS expression correlates with response to 5-FU treatment in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.