Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher의 Amyloid Precursor Protein(APP) 폴리클로날 항체로 Western blot, IHC, Flow Cytometry에 적합. 인간 및 생쥐 반응성. KLH 결합 합성 펩타이드 면역원 사용. 0.5 mg/mL 농도의 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
- 카탈로그번호
- PA513327
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 29–61 amino acids from the N-terminal region of human APP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion Dialysis, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2056551 |
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1. APP plays a critical role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with several isoforms generated by alternative splicing. Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques — a hallmark of Alzheimer’s disease. Abnormal APP regulation and processing are also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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