Thermo Fisher Scientific PARP12 Polyclonal Antibody
PARP12 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 등에 사용 가능. Human 및 Mouse 시료에 반응하며, KLH 결합 합성 펩타이드로 면역 생성. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of mouse Parp12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Size-exclusion - Dialysis, Ammonium sulfate precipitation |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2251889 |
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain. Among them, PARP-1 (113 kDa) and PARP-2 (62 kDa) are the only enzymes whose catalytic activity is immediately stimulated by DNA strand breaks.
A large repertoire of sequences encoding novel PARPs extends the field of poly(ADP-ribosyl)ation reactions to various aspects of cell biology, including cell proliferation and cell death. Some of these new members interact with each other, share common partners and subcellular localizations, suggesting possible fine-tuning in the regulation of this post-translational modification of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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