Thermo Fisher Scientific Claudin 2 Polyclonal Antibody
Claudin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, Human 및 Mouse 반응성을 보입니다. 고순도 Protein A 및 Antigen affinity chromatography로 정제되어 안정적인 결과를 제공합니다.
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Thermo Fisher Scientific Claudin 2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 135–164 amino acids from the N-terminal region of human Claudin 2 (CLDN2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2245102 |
Product Specific Information
This antibody is predicted to react with bovine and mouse based on sequence homology.
Target Information
Tight junctions are specialized regions of cell-cell contact abundant in luminal epithelial cell sheets. In freeze-fracture electron micrographs, tight junctions appear as belt-like bands of sealing strands encircling each cell. These strands form a molecular gasket preventing ions and molecules from leaking between cells.
Tight junctions also maintain epithelial polarity by blocking diffusion of membrane proteins between apical and basolateral surfaces. Proteins such as ZO-1, ZO-2, ZO-3, cingulin, Rab-3b, and symplekin are associated with tight junctions, contributing to assembly, maintenance, and permeability regulation.
Claudin-1 and Claudin-2 are major structural components of tight junction strands, inducing networks typical of true tight junctions. Claudin-2 functions as a paracellular channel selective for cations (Na+) and is primarily expressed in liver and kidney, with minor expression in the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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