Thermo Fisher Scientific IFI16 Recombinant Rabbit Monoclonal Antibody (8H37L1)
Thermo Fisher Scientific의 IFI16 재조합 Rabbit Monoclonal Antibody (8H37L1)은 인간 IFI16 단백질을 표적으로 하는 고특이성 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, Expi293 시스템에서 발현된 단클론 항체입니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8H37L1 |
| Immunogen | Protein corresponding to human IFI16 (aa571–aa766 and aa446–aa571) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2811729 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
IFI16 (gamma-interferon-inducible protein 16) binds double-stranded DNA, preferentially to supercoiled and cruciform DNA structures. It is involved in transcriptional regulation and acts as a transcriptional repressor. IFI16 may regulate hematopoietic differentiation by activating unknown target genes and controls cellular proliferation through modulation of cell cycle regulatory factors such as p53/TP53 and retinoblastoma protein.
IFI16 also plays a role in innate immune response by recognizing viral dsDNA in the cytosol and nucleus. Upon binding viral DNA, it recruits TMEM173/STING and induces IFN-beta production. It is essential for activation of the IFR3 signaling cascade during human herpes simplex virus 1 infection, promoting heterochromatin assembly on viral DNA and inhibiting immediate-early gene expression and replication.
Additionally, IFI16 is involved in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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