Thermo Fisher Scientific Phospho-INSR (Tyr1355) Polyclonal Antibody
인간 INSR Tyr1355 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot과 IHC(P)에서 검증됨. 비결합형 액상 형태로 제공되며 농도는 1 mg/mL. -20°C 보관, Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human INSR around the phosphorylation site of Tyr1355 (R-S-YP-E-E) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554883 |
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates the biological actions of insulin. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarities. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may also contribute to certain forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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