Thermo Fisher Scientific Human APRIL Recombinant Protein, PeproTech
Recombinant human APRIL 단백질로 NF-κB 활성 유도 기능 검증 완료. 인간 및 마우스에서 발현된 TNF 슈퍼패밀리 구성원으로 면역 반응과 세포 사멸 조절에 관여. ≥95% 순도, endotoxin <1 EU/µg, 동결건조 형태로 연구용 적합.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (4)
Miscellaneous PubMed (Misc)
- Refer to publications (2)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse |
| Expression System | Insect cells |
| Amino Acid Sequence | AVLTQKQK...LGFVKL (146 amino acids) |
| Molecular Weight | 16.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | < 1 EU/µg |
| Activity | Induces NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- Catalog 310-10C-01M: 20 × 50 µg (310-10C-50UG)
- Catalog 310-10C-500: 10 × 50 µg (310-10C-50UG)
- Catalog 310-10C-250: 5 × 50 µg (310-10C-50UG)
- Catalog 310-10C-100: 2 × 50 µg (310-10C-50UG)
Recombinant human APRIL is a soluble 16.3 kDa protein consisting of 146 amino acid residues.
Human APRIL (Catalog Number 310-10C) has replaced Human APRIL (Catalog Number 310-10).
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Members of the TNF superfamily regulate immune responses and induce apoptosis.
APRIL (A Proliferation-Inducing Ligand), also known as TALL2 and TRDL1a, is a novel TNF family member identified in human and mouse.
Two receptors for APRIL—TACI and BCMA—mediate its biological effects. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death.
APRIL, BlyS, and their receptors BCMA and TACI are implicated in autoimmune diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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