Thermo Fisher Scientific Human 4-1BB Ligand (TNFSF9) Recombinant Protein, PeproTech
Recombinant Human 4-1BB Ligand (TNFSF9) 단백질로, 인간 PBMC에서 IL-8 생산을 자극하는 생물학적 활성을 가집니다. E. coli 발현 시스템에서 생산되었으며, ≥98% 순도와 낮은 endotoxin 수준을 보장합니다. 면역세포 활성화 연구 및 기능 분석용으로 적합합니다.
- 카탈로그번호
- 310-11-xxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
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6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human 4-1BB Ligand (TNFSF9) Recombinant Protein, PeproTech
Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Functional Assay
- Assay-dependent
In vitro Assay
- Assay-dependent
View 3 publications
Miscellaneous (PubMed)
- Assay-dependent
View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE |
| Molecular Weight | 19.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Dose-dependent stimulation of IL-8 production by human PBMC (ED50: 5–10 ng/ml). Results may vary with PBMC donors. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and a member of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells such as dendritic cells, monocytes/macrophages, and B cells, and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells including inflamed endothelial cells, where interaction with CD137L enhances monocyte extravasation. Activated T cells express CD137, and engagement with CD137L promotes T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is also expressed in most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell) but absent in Hodgkin and T-cell lymphomas. It is also found in carcinoma cell lines, suggesting involvement in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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