Thermo Fisher Scientific Human APRIL Recombinant Protein, PeproTech

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

-

In vitro Assay (IV)

-

View 4 publications 4 publications

Miscellaneous PubMed (Misc)

-

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

Insect cells

Amino acid sequence

AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL

Molecular weight

16.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to induce NF-kappaB activation in HEK293-NF-kappaB reporter cells transfected with BCMA receptor.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Product Specific Information

310-10C-01M will be provided as 20 x 50 µg (310-10C-50UG).

310-10C-500 will be provided as 10 x 50 µg (310-10C-50UG).

310-10C-250 will be provided as 5 x 50 µg (310-10C-50UG).

310-10C-100 will be provided as 2 x 50 µg (310-10C-50UG)

Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues. *Human APRIL (Catalog Number 310-10C) has replaced Human APRIL (Catalog Number 310-10).

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.