Thermo Fisher Scientific Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody
Synaptotagmin 1의 Thr202 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot 및 ICC/IF에 사용 가능. 다양한 종에 교차반응 예측. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr202 of rat SYT1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560618 |
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, and zebrafish based on 100% sequence homology.
It is specific for the ~60–62 kDa Synaptotagmin protein phosphorylated at Ser309 in Western blots of rat brain lysates.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS, acting as a Ca²⁺ sensor in exocytosis and neurotransmitter release.
Its Ca²⁺-mediated binding of SNAP25 is essential for the Ca²⁺-dependent triggering of membrane fusion.
Residues within the C2B domain independently regulate endocytic rate and synaptic vesicle size.
Synaptotagmin 1 binds acidic phospholipids requiring both an acidic head group and a diacyl backbone.
It interacts in a Ca²⁺-dependent manner with receptors for activated protein kinase C and also binds neurexins, syntaxin, and AP2 in a Ca²⁺-independent manner.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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