Thermo Fisher Scientific ASIC1 Polyclonal Antibody
ASIC1 단백질을 인식하는 Thermo Fisher Scientific의 기니피그 유래 polyclonal 항체. IHC(P)에서 1:10~1:500 희석으로 사용 가능하며, rat spinal cord를 양성 대조군으로 추천. ASIC1 단백질의 뇌 발현 연구 및 이온 채널 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues A(3) G S E L D E G D D S P R D L V(18) of rat ASIC Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1954753 |
Product Specific Information
- Suggested positive control: rat spinal cord
- Staining was blocked by preabsorption with the cognate peptide
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels containing intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop with conserved cysteine residues.
The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. It acts as a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampus, amygdala, and cerebellum. Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is found in DRG, spinal cord, trigeminal ganglia, and mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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