Thermo Fisher Scientific Phospho-CHK2 (Ser19) Polyclonal Antibody
CHK2 단백질의 Ser19 인산화 상태를 검출하는 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, DNA 손상 반응 연구에 유용. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 인산화 신호전달 및 암 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Positive Control: 293T, 293T (100 µM Etoposide treatment for 2 hr)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Chk2 (phospho Ser19). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736362 |
Product Specific Information
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer usually associated with inherited mutations in TP53. Mutations in CHK2 are also thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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