Thermo Fisher Scientific Phospho-MEK1 (Thr292) Polyclonal Antibody
Phospho-MEK1 (Thr292) 폴리클로날 항체로, 인간·생쥐·랫트에서 인산화된 MEK1 검출에 최적화. Western blot 및 면역세포염색에 사용 가능. 고순도 정제, 1 mg/mL 농도, PBS/glycerol 버퍼에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA5104954
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K1 (Accession Q02750), corresponding to amino acid residues around phosphorylated Thr292 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816427 |
Product Specific Information
This antibody detects endogenous levels of MEK1 only when phosphorylated at Threonine 292.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in the mitogen-activated protein kinase (MAPK) cascades, which control cell growth and differentiation.
MAP2K1 is activated by various growth factors, cytokines, membrane depolarization, and calcium influx.
MEK1 activation occurs via phosphorylation of serine residues 218 and 222 by Raf1.
It plays a role in stress response signaling, apoptosis, and cytokine-induced proliferation.
Mutations in this gene can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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