Thermo Fisher Scientific RBM4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93%; Dog: 93%; Goat: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

RNA-binding factor involved in multiple aspects of cellular processes such as alternative splicing of pre-mRNA and translation regulation.

• Modulates alternative 5′-splice site and exon selection
• Acts as a muscle cell differentiation-promoting factor
• Activates exon skipping of PTB pre-mRNA during muscle cell differentiation
• Antagonizes splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin
• Binds intronic pyrimidine-rich sequences in TPM1 and MAPT pre-mRNAs
• Required for translational activation of PER1 mRNA in response to the circadian clock
• Binds directly to the 3′-UTR of PER1 mRNA
• Suppresses Cap-dependent translation via CU-rich 3′UTR elements under stress or differentiation conditions
• Recruits EIF4A1 to stimulate IRES-dependent translation initiation under stress
• Associates with internal ribosome entry segments (IRES) in target mRNAs
• Promotes miRNA-guided RNA cleavage and translation suppression by facilitating AGO2-miRNP association with target mRNAs
• Associates with miRNAs during muscle cell differentiation
• Binds preferentially to 5′-CGCGCG[GCA]-3′ motif in vitro
  [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.