Thermo Fisher Scientific Nova-2 Polyclonal Antibody
Nova-2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 Western blot에 적합. 고순도 Protein A 정제, 액상 형태, 1.0 mg/mL 농도. 신경 발달 및 POMA 관련 연구용으로 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1.25 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human Nova-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691437 |
Product Specific Information
This target displays homology in the following species:
Cow: 77%; Dog: 77%; Guinea Pig: 77%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 77%; Zebrafish: 100%
Target Information
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder mediated by autoimmune attack against onconeural antigens expressed by gynecologic or lung tumors and neurons. Nova-1 and Nova-2 are both POMA disease antigens.
Autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1 and is highly expressed in neurons during development and at lower levels in adult lung.
In postnatal mouse brain, Nova-2 is expressed reciprocally with Nova-1, showing high levels in the neocortex and hippocampus. Both Nova proteins are RNA-binding proteins that regulate neuronal pre-mRNA splicing by directly binding RNA. Nova-2 target genes function in synapse or axon guidance, indicating its major role in synaptic function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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